Monday, December 3, 2018

New Research Shows that Certain Oral Bacteria that Cause Periodontal Disease may also Cause Esophageal Cancer

My good friend and co-worker at DPR, Kristen Mott, has written a  good article about a recent discovery that the bacteria that cause periodontal disease (gum disease) may also be linked to esophageal cancer.  While only about 1% of cancers diagnosed in the U.S. each year, it is a terribly debilitating disease.  Also, 1% seems like a small number until you read that it represents 17,290 new cases this year.
Here’s a portion of Kristen’s well written article:

Oral bacteria has been linked to a wide range of serious medial conditions, including pancreatic cancer, stroke and lung cancer. New research shows that oral bacteria may also be linked to esophageal cancer.

Esophageal cancer makes up about 1 percent of all cancers diagnosed in the United States. The American Cancer Society estimates that about 17,290 new esophageal cancer cases will be diagnosed in 2018.

While previous research has shown that periodontal disease caused by certain oral bacteria has been linked to several types of cancer, Jiyoung Ahn, an associate professor in the department of population health and the department of environmental medicine at NYU Langone Health in New York, wanted to investigate the connection between oral microbiota and the risk of esophageal adenocarcinoma (EAC) or esophageal squamous cell carcinoma (ESCC).

According to the study, Ahn and her colleagues collected oral wash samples from 122,000 participants in two large health studies: the American Cancer Society Cancer Prevention Study II Nutrition cohort and the National Cancer Institute Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. According to the research, in 10 years of follow-up, 106 participants developed esophageal cancer.

In a prospective case-control study, the researchers extracted DNA and sequenced oral wash samples, which allowed them to compare the oral microbiomes of the esophageal cancer cases and the cancer-free cases. Certain bacteria types were found to be associated with a higher risk of esophageal cancer, such as the Tannerella forsythia bacteria, which was associated with a 21 percent increased risk of EAC. Another periodontal pathogen, Porphyromonas gingivitis, was associated with a higher risk of ESCC.

However, the researchers also discovered that a few types of oral bacteria were associated with a lower risk of EAC. Bacterial biosynthesis of carotenoids was also associated with protection against esophageal cancer, according to the study. Ahn told Science Daily that certain bacteria may actually have a protective effect, and future research on the topic is required.

The American Dental Association says additional research is needed to examine whether certain bacteria could play a role in preventing esophageal cancer.

For the full text of the article, follow this link to Dental Products Report.  

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